Long term

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Long term

Cocaine What are the long-term effects of cocaine use?

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With repeated exposure to cocaine, the brain starts to adapt so that the reward pathway becomes less sensitive to natural reinforcers 1018 see " What Are Some Ways that Cocaine Changes the Brain?

At the same time, circuits involved in stress become increasingly sensitive, leading to increased displeasure and negative moods when not taking the drug, which are signs of withdrawal.

Long term

These combined effects make the user more likely to focus on seeking the drug instead of relationships, food, or other natural rewards.

With Long term use, tolerance may develop so that higher doses, more frequent use of cocaine, or both are needed to produce the same level of pleasure and relief from withdrawal experienced initially.

Users take cocaine in binges, in which cocaine is used repeatedly and at increasingly higher doses. This can lead to increased irritability, restlessness, panic attacks, paranoia, and even a full-blown psychosis, in which the individual loses touch with reality and experiences auditory hallucinations.

Specific routes of cocaine administration can produce their own adverse effects.

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Regularly snorting cocaine can lead to loss of sense of smell, nosebleeds, problems with swallowing, hoarseness, and an overall irritation of the nasal septum leading to a chronically inflamed, runny nose. They also may experience allergic reactions, either to the drug itself or to additives in street cocaine, which in severe cases can result in death.

Cocaine damages many other organs in the body. It reduces blood flow in the gastrointestinal tract, which can lead to tears and ulcerations.

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Cocaine has significant and well-recognized toxic effects on the heart and cardiovascular system. Research indicates that during periods of abstinence, the memory of the cocaine experience or exposure to cues associated with drug use can trigger strong cravings, which can lead to relapse.Acknowledgements This report was edited by Eduardo Sabaté,WHO Medical Officer responsible for coordinating the WHO Adherence to Long-term Therapies .

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Long term

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(See the commentary by Moro, on pages –)Infection surveillance definitions for long-term care facilities (ie, the McGeer Criteria) have not been updated.

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What happened long before Russia hacked the DNC's emails. long - Translation to Spanish, pronunciation, and forum discussions. Discussion. The probability of long-term opioid use increases most sharply in the first days of therapy, particularly after 5 days or 1 month of opioids have been prescribed, and levels off after approximately 12 weeks of therapy.

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